Università Politecnica delle Marche, Italy

Post-Doc, Dipartimento di Scienze della Vita e dell’Ambiente

Thesis Title: Development of stem cell technological solutions for allogeneic therapy of equine musculoskeletal injury

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The principal aim of the doctoral research was to define an effective protocol for in vitro isolation, selection and expansion of Mesenchymal Stem Cells (MSC) from equine fetal adnexa and to characterise the resulting cell populations for expression of MSC-specific markers, and competence for growth and differentiation in vitro and following cryopreservation. Specifically, the project has sought to prepare homogeneous MSC subpopulations from Umbilical Cord Matrix (UCM) and, for the first time, to define a procedure to obtain MSCs from amniotic (both epithelial and mesenchymal) membranes, so that ultimately they were used for the treatment of tendon injuries in horses by allogeneic cell transplantation. Preliminary data showed that equine placenta holds good expectations as a source of stem cells. These cells have been extensively characterised for their immunomodulatory effect as well as their ability to regenerate damaged tissue in horse tendons in vivo.

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